Symantec Endpoint Protection 11 (SEP 11) includes a feature called Proactive Threat Protection, which seeks out suspicious behavior on your computer, and isolates it. Since brand new viruses may not always be immediately detected by antivirus software, Proactive Threat Protection is a good barrier against the unknown.
Unfortunately, sometimes have noticed that their Proactive Threat Protection defitions are stuck or not update day by day.
Solution:
Delete the string value “Sequence Number” under the following registry keys:
HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\COH_PVLInfo\COHData
HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\COH_PVLInfo\COHEngine
Exit the registry and restart your system.
IF problem not solve, then try this one:
Modify the value of the following DWORD registry entry to 1:
HKEY_LOCAL_MACHINE\Software\Symantec\Symantec Endpoint Protection\LiveUpdate\SyknappsContentListReady
Note: If this registry entry does not exist on the client, create the entry and set it to the value above
Run command : smc -stop
smc -start
or Reboot the system.